The GDRF primary mission is finding a cure for GRIN genes disorders.
The foundation mainly supports translational and clinical research.
The GDRF follows the following definitions, adopted from various sources (Horizon2020, NIH, and more)
Basic research – also called pure research or fundamental research, has the scientific research aim to improve scientific theories for improved understanding or prediction of natural or other phenomena (more).
Functional research – also known as Functional Genomics uses genomic data to study gene and protein expression and function on a global scale (genome-wide or system-wide), focusing on gene transcription, translation and protein-protein interactions, and often involving high-throughput methods.
Translational research – fosters the multidirectional and multidisciplinary integration of basic research, patient-oriented research, and population-based research, with the long-term aim of improving the health of the public.
Clinical research – Research in which people, or data or samples of tissue from people, are studied to understand health and disease. Clinical research helps find new and better ways to detect, diagnose, treat, and prevent disease. Types of clinical research include clinical trials, which test new treatments for a disease, and natural history studies, which collect health information to understand how a disease develops and progresses over time.
Personalised Medicine – also known as ‘precision medicine’ and ‘stratified medicine’, refers to a medical model using characterisation of individuals’ phenotypes and genotypes (e.g. molecular profiling, medical imaging, lifestyle data) for tailoring the right therapeutic strategy for the right person at the right time, and/or to determine the predisposition to disease and/or to deliver timely and targeted prevention.
As a parents-run organization, the GDRF focuses on finding a cure to our dearests who live with ultra-rare diseases in a reasonable time and with limited resources.
We incline to support research which may evolve into either a Drug therapy or a Gene therapy.
We forgo research which does not have a feasible practical merit. Please advise that since Functional Analysis is already available for the GRIN disorders, as a service provided by multiple institutes (list), we no longer see the need to support it.
GDRF affiliated research
At the GDRF, we strongly believe that only research based on a wide range of multidisciplinary activities and collaboration between different stakeholders from academia (e.g.universities, higher education institutions, public research institutions) and clinics (e.g. clinical laboratories, medical professionals) will lead us to our objective.
The overarching goal is to improve disease management, based on broader and more efficiently elaborated patient stratification, diagnostics and tailored treatment protocols.
The GDRF acts both as financer and as a coordinator for many research groups. It provides any researcher the platform to meet fellows and it seeks to facilitate joint grant applications and multidisciplinary, cross-sectoral and transnational collaborations, with emphasis on the field of personalized medicine.